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Target
Prolyl endopeptidase
Ligand
BDBM50279825
Substrate
n/a
Meas. Tech.
ChEBML_157466
Ki
3±n/a nM
KOFF
0.002000 s-1
KON
700000 M-1s-1
Citation
 Bakker, AV; Daffeh, J; Jung, S; Vincent, LA; Nagel, AA; Spencer, RW; Vinick, FJ; Faraci, WS Novel in vitro and in vivo inhibitors of prolyl endopeptidase Bioorg Med Chem Lett 1:585-590 (1991)    Article 
Target
Name:
Prolyl endopeptidase
Synonyms:
PE | PPCE_MOUSE | Pep | Post-proline cleaving enzyme | Prep
Type:
PROTEIN
Mol. Mass.:
80738.55
Organism:
Mus musculus
Description:
ChEMBL_1336164
Residue:
710
Sequence:
MLSFQYPDVYRDETSVQEYHGHKICDPYSWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIWEGCDPVNRLWYCDLQQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTKEELEPMVFREVTVKGIDAADYQTIQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYGCSDTKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIEWIQ
  
Inhibitor
Name:
BDBM50279825
Synonyms:
(1R,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cyclohexanecarboxylic acid benzyl ester | CHEMBL154968
Type:
Small organic molecule
Emp. Form.:
C20H25NO4
Mol. Mass.:
343.4168
SMILES:
O=C[C@@H]1CCCN1C(=O)[C@H]1CCCC[C@H]1C(=O)OCc1ccccc1
Structure:
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