Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50030004
Substrate
n/a
Meas. Tech.
ChEMBL_201036 (CHEMBL803262)
Ki
0.700000±n/a nM
Citation
 Liu, YSvensson, BEYu, HCortizo, LRoss, SBLewander, THacksell, U C8-substituted derivatives of 2-(dipropylamino)tetralin: Palladium-catalyzed synthesis and interactions with 5-HT1A-receptors Bioorg Med Chem Lett 1:257-262 (1991)    Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50030004
Synonyms:
1-((S)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-yl)-ethanone | 1-(7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-yl)-ethanone | CHEMBL87195
Type:
Small organic molecule
Emp. Form.:
C18H27NO
Mol. Mass.:
273.4131
SMILES:
CCCN(CCC)[C@H]1CCc2cccc(C(C)=O)c2C1
Structure:
Search PDB for entries with ligand similarity: