Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50280422
Substrate
n/a
Meas. Tech.
ChEMBL_48789 (CHEMBL662442)
IC50
280±n/a nM
Citation
 Ashton, MJ; Bridge, AW; Bush, RC; Dron, DI; Harris, NV; Jones, GD; Lythgoe, DJ; Riddell, D; Smith, C RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT) Bioorg Med Chem Lett 2:375-380 (1992)    Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50280422
Synonyms:
1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-pentyl]-1H-pyrazole | CHEMBL264816
Type:
Small organic molecule
Emp. Form.:
C23H24N4S
Mol. Mass.:
388.528
SMILES:
C(CCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)CCn1cccn1
Structure:
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