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Target
5-hydroxytryptamine receptor 3A/3B
Ligand
BDBM50280497
Substrate
n/a
Meas. Tech.
ChEMBL_3006 (CHEMBL619796)
Ki
0.900000±n/a nM
Citation
 Langlois, M; Soulier, JL; Brémont, B; Shen, S; Rampillon, V; Giudice, A Derivatives of naphthalimide: new potent conformationally restricted antagonists of 5-HT3 receptors. Bioorg Med Chem Lett 2:691-694 (1992)    Article 
Target
Name:
5-hydroxytryptamine receptor 3A/3B
Synonyms:
Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 2974
Components:
This complex has 2 components.
Component 1
Name:
5-hydroxytryptamine receptor 3B
Synonyms:
5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor
Type:
PROTEIN
Mol. Mass.:
50328.78
Organism:
Rattus norvegicus
Description:
EBI_11885
Residue:
437
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTESPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVLGLYTVTLCSLWALWSRM
  
Component 2
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55428.70
Organism:
RAT
Description:
5-HT3 HTR3A RAT::P35563
Residue:
483
Sequence:
MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS
  
Inhibitor
Name:
BDBM50280497
Synonyms:
(R)-2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-benzo[de]isoquinoline-1,3-dione | CHEMBL161922
Type:
Small organic molecule
Emp. Form.:
C19H18N2O2
Mol. Mass.:
306.3584
SMILES:
O=C1N([C@H]2CN3CCC2CC3)C(=O)c2cccc3cccc1c23 |wD:3.2,(9.94,-6.84,;9.08,-5.56,;9.79,-4.16,;11.33,-4.09,;12.15,-5.37,;13.69,-5.3,;14.38,-3.93,;13.53,-2.64,;11.99,-2.71,;12.41,-4.2,;13.41,-3.73,;8.94,-2.87,;9.63,-1.49,;7.39,-2.96,;6.57,-1.7,;5.04,-1.78,;4.35,-3.15,;5.17,-4.41,;4.48,-5.79,;5.31,-7.08,;6.85,-7,;7.55,-5.65,;6.7,-4.34,)|
Structure:
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