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Target
Neutrophil elastase
Ligand
BDBM50281010
Substrate
n/a
Meas. Tech.
ChEMBL_63974 (CHEMBL677600)
Ki
310000±n/a nM
Citation
 Finke, PE; Dahlgren, ME; Weston, H; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 5. Inhibition by 6-alkyl substituted penem benzyl esters. Bioorg Med Chem Lett 3:2277-2282 (1993)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50281010
Synonyms:
(R)-3-Methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzyl ester | CHEMBL307886
Type:
Small organic molecule
Emp. Form.:
C14H13NO3S
Mol. Mass.:
275.323
SMILES:
CC1=C(N2[C@@H](CC2=O)S1)C(=O)OCc1ccccc1 |t:1|
Structure:
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