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Target
Substance-P receptor
Ligand
BDBM50281198
Substrate
n/a
Meas. Tech.
ChEBML_143028
IC50
17±n/a nM
Citation
 Mills, SG; Wu, MT; MacCoss, M; Budhu, RJ; Dorn, CP; Cascieri, MA; Sadowski, S; Strader, CD; Greenlee, WJ 1,4-Diacylpiperazine-2-(S)-[(N-aminoalkyl)carboxamides] as novel, potent substance P receptor antagonists. Bioorg Med Chem Lett 3:2707-2712 (1993)    Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50281198
Synonyms:
(S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentylamide 1-diphenylamide 2-({2-[(2-methoxy-benzyl)-methyl-amino]-ethyl}-methyl-amide) | CHEMBL431459
Type:
Small organic molecule
Emp. Form.:
C41H58N6O4
Mol. Mass.:
698.937
SMILES:
CCCCCN(CCCCC)C(=O)N1CCN([C@@H](C1)C(=O)N(C)CCN(C)Cc1ccccc1OC)C(=O)N(c1ccccc1)c1ccccc1
Structure:
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