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Target
Endothelin receptor type B
Ligand
BDBM50045227
Substrate
n/a
Meas. Tech.
ChEBML_64037
IC50
4000±n/a nM
Citation
 Doherty, AM; Cody, WL; He, JX; DePue, PL; Leonard, DM; Jr., JD; Hill, KE; Flynn, MA; Reynolds, EE Design of C-terminal peptide antagonists of endothelin: structure-activity relationships of ET-[16–21, D-His16] Bioorg Med Chem Lett 3:497-502 (1993)    Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49483.43
Organism:
RAT
Description:
ENDOTHELIN B EDNRB RAT::P21451
Residue:
442
Sequence:
MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50045227
Synonyms:
(S)-3-[2-((R)-2-Acetylamino-3-phenyl-propionylamino)-5-amino-pentanoylamino]-N-{(S)-1-[(S)-1-((S)-carboxy-2-(S)-1-1H-indol-3-yl-ethylcarbamoyl)-2-(S)-methyl-butylcarbamoyl]-2-methyl-butyl}-succinamic acid | Ac-D-Phe-Orn-Asp-Ile-Ile-Trp | CHEMBL2370070
Type:
Small organic molecule
Emp. Form.:
C43H60N8O10
Mol. Mass.:
848.9841
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Structure:
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