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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50282003
Substrate
n/a
Meas. Tech.
ChEBML_162611
IC50
30±n/a nM
Citation
 Holmes, DS; Bethell, RC; Hann, MM; Kitchin, J; Starkey, ID; Storer, R The design and synthesis of novel hydroxyproline inhibitors of HIV-1 proteinase Bioorg Med Chem Lett 3:1485-1491 (1993)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50282003
Synonyms:
(2R,4S)-2-((R)-Benzylcarbamoyl-phenylacetylamino-methyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid ((S)-5-tert-butylcarbamoyl-3-hydroxy-1-isobutyl-pyrrolidin-3-ylmethyl)-amide | CHEMBL289409
Type:
Small organic molecule
Emp. Form.:
C37H54N6O5S
Mol. Mass.:
694.927
SMILES:
CC(C)CN1CC(O)(CNC(=O)[C@@H]2N[C@H](SC2(C)C)[C@H](NC(=O)Cc2ccccc2)C(=O)NCc2ccccc2)C[C@H]1C(=O)NC(C)(C)C
Structure:
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