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Target
Type-1 angiotensin II receptor
Ligand
BDBM50030727
Substrate
n/a
Meas. Tech.
ChEMBL_217981 (CHEMBL824100)
IC50
0.550000±n/a nM
Citation
 Chang, LL; Ashton, WT; Flanagan, KL; Naylor, EM; Chakravarty, PK; Patchett, AA; Greenlee, WJ; Bendesky, RJ; Chen, TB; Faust, KA; Kling, PJ; Schaffer, LW; Schorn, TW; Zingaro, GJ; Chang, RS; Lotti, VJ; Kivlighn, SD; Siegl, PK Triazolinones as nonpeptide angiotensin II antagonists. 2. discovery of a potent and orally active triazolinone acylsulfonamide Bioorg Med Chem Lett 4:115-120 (1994)    Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50030727
Synonyms:
4''-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,5-dihydro-[1,2,4]triazol-4-ylmethyl]-biphenyl-2-sulfonic acid benzoylamide | CHEMBL279629 | CHEMBL97539 | L-159,913 | L-159913
Type:
Small organic molecule
Emp. Form.:
C33H29F3N4O4S
Mol. Mass.:
634.668
SMILES:
CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Structure:
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