Target
Neutrophil elastase
Ligand
BDBM50282870
Substrate
n/a
Meas. Tech.
ChEBML_64002
Ki
80±n/a nM
Citation
 Hlasta, DJBell, MRBoaz, NWCourt, JJDesai, RCFranke, CAMura, AJSubramanyam, CDunlap, RP A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase Bioorg Med Chem Lett 4:1801-1806 (1994)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50282870
Synonyms:
1,1-Dioxo-4-phenyl-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL301744
Type:
Small organic molecule
Emp. Form.:
C21H15N5O3S2
Mol. Mass.:
449.506
SMILES:
O=C1N(CSc2nnnn2-c2ccccc2)S(=O)(=O)c2cccc(c12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: