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Target
Type-2 angiotensin II receptor
Ligand
BDBM50283301
Substrate
n/a
Meas. Tech.
ChEBML_35429
IC50
32±n/a nM
Citation
 Glinka, TW; de Laszlo, SE; Siegl, PK; Chang, RS; Kivlighn, SD; Schorn, TS; Faust, KA; Chen, TB; Zingaro, GJ; Lotti, VJ; Greenlee, WJ Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes. Bioorg Med Chem Lett 4:2337-2342 (1994)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50283301
Synonyms:
2-ethyl-3-(3-fluoro-2'-(butyloxycarbonylaminosulphonyl)-biphenyl-4-ylmethyl)-6-(morpholinylcarbonylamino)-3H-quinazolin-4-one | CHEMBL307290
Type:
Small organic molecule
Emp. Form.:
C33H36FN5O7S
Mol. Mass.:
665.732
SMILES:
CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1
Structure:
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