BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAcyl coenzyme A:cholesterol acyltransferase 1
LigandBDBM50450320
Substrate/Competitorn/a
Meas. Tech.ChEBML_28027
IC50 2140±n/a nM
Citation Wilde, RJBillheimer, JTGermain, SJGillies, PJHigley, CAKezar, HSMaduskuie, TPShimshick, ESWexler, RR Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole Bioorg Med Chem Lett5:167-72 (1995)  
More Info.:Get all data from this article,  Assay Method
 
Acyl coenzyme A:cholesterol acyltransferase 1
Name:Acyl coenzyme A:cholesterol acyltransferase 1
Synonyms:ACAT-1 | Acetoacetyl-CoA thiolase | Acetyl-CoA acetyltransferase, mitochondrial | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | Sterol O-acyltransferase 1
Type:PROTEIN
Mol. Mass.:63818.83
Organism:Mus musculus
Description:ChEMBL_90523
Residue:540
Sequence:
MSLRNRLSKSGENPEQDEAQKNFMDTYRNGHITMKQLIAKKRLLAAEAEELKPLFMKEVG
CHFDDFVTNLIEKSASLDNGGCALTTFSILEEMKKNHRAKDLRAPPEQGKIFISRQSLLD
ELFEVDHIRTIYHMFIALLILFVLSTIVVDYIDEGRLVLEFNLLAYAFGKFPTVIWTWWA
MFLSTLSIPYFLFQRWAHGYSKSSHPLIYSLVHGLLFLVFQLGVLGFVPTYVVLAYTLPP
ASRFILILEQIRLIMKAHSFVRENIPRVLNAAKEKSSKDPLPTVNQYLYFLFAPTLIYRD
NYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSI
LPGVLILFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYY
YVYKDLLWFFSKRFKSAAMLAVFALSAVVHEYALAICLSYFYPVLFVLFMFFGMAFNFIV
NDSRKRPIWNIMVWASLFLGYGLILCFYSQEWYARQHCPLKNPTFLDYVRPRTWTCRYVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50450320
NameBDBM50450320
Synonyms:CHEMBL49001
TypeSmall organic molecule
Emp. Form.C31H44N4O2S
Mol. Mass.536.772
SMILESCCCCCCCN(CCCCCSC1=NC(=O)C(N1)(c1ccccc1)c1ccccc1)C(=O)NC(C)C |t:14|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a