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Target
Platelet-activating factor receptor
Ligand
BDBM50035397
Substrate
n/a
Meas. Tech.
ChEBML_155158
Ki
3.8±n/a nM
Citation
 Holms, JH; Davidsen, SK; Sheppard, GS; Carrera, GM; Curtin, NL; Heyman, HR; Pireh, D; Steinman, DH; Albert, DH; Conway, RG; Luo, G; Magoc, TJ; Tapang, P; Rhein, DA; Summers, JB Discovery and optimization of indole pyrrolothiazole paf antagonists Bioorg Med Chem Lett 5:2903-2908 (1995)    Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50035397
Synonyms:
6-(4-Fluoro-phenyl)-3-((R)-3-pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carbonyl)-indole-1-carboxylic acid dimethylamide | CHEMBL98318
Type:
Small organic molecule
Emp. Form.:
C29H23FN4O2S
Mol. Mass.:
510.582
SMILES:
CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c2cccnc2)c2ccc(cc12)-c1ccc(F)cc1
Structure:
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