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Target
Neutrophil elastase
Ligand
BDBM50282878
Substrate
n/a
Meas. Tech.
ChEBML_86695
KOFF
0.000076 s-1
KON
5600 M-1s-1
Citation
 Hlasta, DJ; Bell, MR; Court, JJ; Cundy, KC; Desai, RC; Ferguson, EW; Gordon, RJ; Kumar, V; Maycock, AL; Subramanyam, C; Dunlap, RP; Eiff, SL; Franke, CA; Mura, AJ; Rowlands, AG The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase Bioorg Med Chem Lett 5:331-336 (1995)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50282878
Synonyms:
4-Methoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL432890
Type:
Small organic molecule
Emp. Form.:
C16H13N5O4S2
Mol. Mass.:
403.436
SMILES:
COc1cccc2c1C(=O)N(CSc1nnnn1-c1ccccc1)S2(=O)=O
Structure:
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