Reaction Details Report a problem with these data
Target
Retinoic acid receptor beta
Ligand
BDBM50286562
Substrate
n/a
Meas. Tech.
ChEMBL_195650 (CHEMBL796045)
EC50
930±n/a nM
Citation
 Chandraratna, RA; Gillett, SJ; Song, TK; Attard, J; Vuligonda, S; Garst, ME; Arefieg, T; Gil, DW; Wheeler, L Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs Bioorg Med Chem Lett 5:523-527 (1995)    Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50498.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458015
Residue:
455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
  
Inhibitor
Name:
BDBM50286562
Synonyms:
6-(2,6,6-Trimethyl-cyclohex-1-enylethynyl)-naphthalene-2-carboxylic acid | CHEMBL151672
Type:
Small organic molecule
Emp. Form.:
C22H22O2
Mol. Mass.:
318.4089
SMILES:
CC1=C(C#Cc2ccc3cc(ccc3c2)C(O)=O)C(C)(C)CCC1 |c:1|
Structure:
Search PDB for entries with ligand similarity: