Reaction Details Report a problem with these data
Target
Matrilysin
Ligand
BDBM50287385
Substrate
n/a
Meas. Tech.
ChEBML_102104
IC50
10±n/a nM
Citation
 Chen, JJ; Zhang, Y; Hammond, S; Dewdney, N; Ho, T; Lin, X; Browner, MF; Castelhano, AL Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2′-P3′ amide bond isostere Bioorg Med Chem Lett 6:1601-1606 (1996)    Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50287385
Synonyms:
(R)-N*1*-[1-(1H-Benzoimidazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-N*4*-hydroxy-2-isobutyl-succinamide | CHEMBL40589
Type:
Small organic molecule
Emp. Form.:
C25H29N5O3
Mol. Mass.:
447.5295
SMILES:
CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)c1nc2ccccc2[nH]1
Structure:
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