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Target
Complement C1r subcomponent
Ligand
BDBM50289016
Substrate
n/a
Meas. Tech.
ChEMBL_40172 (CHEMBL655967)
IC50
57000±n/a nM
Citation
 Gilmore, JL; Hays, SJ; Caprathe, BW; Lee, C; Emmerling, MR; Michael, W; Jaen, JC Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors Bioorg Med Chem Lett 6:679-682 (1996)    Article 
Target
Name:
Complement C1r subcomponent
Synonyms:
C1R | C1R_HUMAN | Complement C1r | Complement C1r subcomponent
Type:
Enzyme
Mol. Mass.:
80113.65
Organism:
Homo sapiens (Human)
Description:
P00736
Residue:
705
Sequence:
MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
  
Inhibitor
Name:
BDBM50289016
Synonyms:
5-Chloro-2-(2-iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEMBL161460
Type:
Small organic molecule
Emp. Form.:
C14H7ClINO2
Mol. Mass.:
383.568
SMILES:
Clc1cccc2nc(oc(=O)c12)-c1ccccc1I
Structure:
Search PDB for entries with ligand similarity: