Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50063703
Substrate
n/a
Meas. Tech.
ChEBML_212693
IC50
15300±n/a nM
Citation
 Gilmore, JL; Hays, SJ; Caprathe, BW; Lee, C; Emmerling, MR; Michael, W; Jaen, JC Synthesis and evaluation of 2-aryl-4H-3,1-benzoxazin-4-ones as C1r serine protease inhibitors Bioorg Med Chem Lett 6:679-682 (1996)    Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50063703
Synonyms:
2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEMBL10378
Type:
Small organic molecule
Emp. Form.:
C14H8INO2
Mol. Mass.:
349.1233
SMILES:
Ic1ccccc1-c1nc2ccccc2c(=O)o1
Structure:
Search PDB for entries with ligand similarity: