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Target
Interstitial collagenase
Ligand
BDBM50290444
Substrate
n/a
Meas. Tech.
ChEMBL_70344 (CHEMBL677169)
IC50
20000±n/a nM
Citation
 Miller, A; Askew, M; Beckett, RP; Bellamy, CL; Bone, EA; Coates, RE; Davidson, AH; Drummond, AH; Huxley, P; Martin, FM; Saroglou, L; Thompson, AJ; van Dijk, SE; Whittaker, M Inhibition of Matrix Metalloproteinases: An examination of the S1′ pocket Bioorg Med Chem Lett 7:193-198 (1997)    Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50290444
Synonyms:
(R)-3-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)carbamoyl)undecanoic acid | (R)-3-((S)-2,2-Dimethyl-1-methylcarbamoyl-propylcarbamoyl)-undecanoic acid | CHEMBL418472
Type:
Small organic molecule
Emp. Form.:
C19H36N2O4
Mol. Mass.:
356.5001
SMILES:
CCCCCCCC[C@H](CC(O)=O)C(=O)N[C@H](C(=O)NC)C(C)(C)C
Structure:
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