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Target
Carboxylic ester hydrolase
Ligand
BDBM50060481
Substrate
n/a
Meas. Tech.
ChEBML_41585
IC50
1180±n/a nM
Citation
 Valenti, P; Rampa, A; Bisi, A; Andrisano, V; Cavrini, V; Fin, L; Buriani, A; Giusti, P Acetylcholinesterase inhibition by tacrine analogues Bioorg Med Chem Lett 7:2599-2602 (1997)    Article 
Target
Name:
Carboxylic ester hydrolase
Synonyms:
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | BuChE | Butyrylcholinesterase (BuChE) | butyrylcholinesterase precursor
Type:
Enzyme
Mol. Mass.:
67776.22
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
597
Sequence:
MVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFPGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEKLVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYNIICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAPQCQFWRLFFPKVLEITGDIDEREQEWKAGFHRWSNYMMDWKNQFNDYTSKKETCTDL
  
Inhibitor
Name:
BDBM50060481
Synonyms:
5,6-Dihydro-benzo[c]acridin-7-ylamine | 5,6-dihydrobenzo[c]acridin-7-amine | CHEMBL89012
Type:
Small organic molecule
Emp. Form.:
C17H14N2
Mol. Mass.:
246.3065
SMILES:
Nc1c2CCc3ccccc3-c2nc2ccccc12
Structure:
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