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Target
Serine protease 1
Ligand
BDBM50290996
Substrate
n/a
Meas. Tech.
ChEBML_212338
IC50
0.760000±n/a nM
Citation
 Semple, JE; Rowley, DC; Brunck, TK; Ripka, WC Synthesis and biological activity of P2–P4 azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives: a novel class of serine protease inhibitors Bioorg Med Chem Lett 7:315-320 (1997)    Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50290996
Synonyms:
3-tert-Butoxycarbonylamino-4-[2-(4-guanidino-1-phenethylaminooxalyl-butylcarbamoyl)-pyrrolidin-1-yl]-4-oxo-butyric acid | CHEMBL106202
Type:
Small organic molecule
Emp. Form.:
C29H43N7O8
Mol. Mass.:
617.6938
SMILES:
CC(C)(C)OC(=O)N[C@@H](CC(O)=O)C(=O)N1CCCC1C(=O)N[C@@H](CCCNC(N)=N)C(=O)C(=O)NCCc1ccccc1
Structure:
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