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Target
Endothelin-1 receptor
Ligand
BDBM50291473
Substrate
n/a
Meas. Tech.
ChEBML_65628
IC50
308±n/a nM
Citation
 Raju, B; Okun, I; Stavros, F; Chan, MF Search for surrogates: A study of endothelin receptor antagonist structure activity relationships Bioorg Med Chem Lett 7:933-938 (1997)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50291473
Synonyms:
2-(2,4-Dimethyl-phenoxymethyl)-thiophene-3-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide | CHEMBL367776
Type:
Small organic molecule
Emp. Form.:
C17H17BrN2O4S2
Mol. Mass.:
457.362
SMILES:
Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc(C)cc2C)c1Br
Structure:
Search PDB for entries with ligand similarity: