Reaction Details Report a problem with these data
Target
Endothelin receptor type B
Ligand
BDBM50291478
Substrate
n/a
Meas. Tech.
ChEBML_63708
IC50
15600±n/a nM
Citation
 Raju, B; Okun, I; Stavros, F; Chan, MF Search for surrogates: A study of endothelin receptor antagonist structure activity relationships Bioorg Med Chem Lett 7:933-938 (1997)    Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50291478
Synonyms:
2-p-Tolyloxymethyl-thiophene-3-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide | CHEMBL172538
Type:
Small organic molecule
Emp. Form.:
C16H15BrN2O4S2
Mol. Mass.:
443.335
SMILES:
Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc(C)cc2)c1Br
Structure:
Search PDB for entries with ligand similarity: