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TargetTyrosine-protein kinase V-ABL
LigandBDBM50292494
Substrate/Competitorn/a
Meas. Tech.ChEMBL_506213
IC50 1±n/a nM
Citation Chang, CJGeahlen, RL Protein-Tyrosine Kinase Inhibition: Mechanism-Based Discovery of Antitumor Agents J Nat Prod55:1529-1560 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase V-ABL
Name:Tyrosine-protein kinase V-ABL
Synonyms:ABL | Tyrosine-protein kinase V-ABL | Tyrosine-protein kinase transforming protein Abl | v-Abl
Type:Enzyme
Mol. Mass.:81895.89
Organism:Abelson murine leukemia virus
Description:P00521
Residue:746
Sequence:
YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50292494
NameBDBM50292494
Synonyms:CHEMBL485064 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}({[hydroxy({[hydroxy(phenoxy)phosphoryl]oxy})phosphoryl]oxy})phosphinic acid
TypeSmall organic molecule
Emp. Form.C16H20N5O13P3
Mol. Mass.583.277
SMILESNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)Oc2ccccc2)[C@@H](O)[C@H]1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a