Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50292638
Substrate
n/a
Meas. Tech.
ChEMBL_496613 (CHEMBL1003788)
IC50
>10000±n/a nM
Citation
 Bongartz, JP; Buntinx, M; Coesemans, E; Hermans, B; Lommen, GV; Wauwe, JV Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists. Bioorg Med Chem Lett 18:5819-23 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50292638
Synonyms:
(+)-1'-(4-bromobenzyl)-N,3-diphenyl-3,4'-bipiperidine-1-carboxamide | (+/-)-1'-(4-bromobenzyl)-N,3-diphenyl-3,4'-bipiperidine-1-carboxamide | (-)-1'-(4-bromobenzyl)-N,3-diphenyl-3,4'-bipiperidine-1-carboxamide | CHEMBL497799
Type:
Small organic molecule
Emp. Form.:
C30H34BrN3O
Mol. Mass.:
532.514
SMILES:
Brc1ccc(CN2CCC(CC2)C2(CCCN(C2)C(=O)Nc2ccccc2)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: