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Target
Bcl-2-like protein 1
Ligand
BDBM50293171
Substrate
n/a
Meas. Tech.
ChEMBL_496943 (CHEMBL1002038)
Kd
3.77E5±n/a nM
Citation
 Janssen, CO; Lim, S; Lo, EP; Wan, KF; Yu, VC; Lee, MA; Ng, SB; Everett, MJ; Buss, AD; Lane, DP; Boyce, RS Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl. Bioorg Med Chem Lett 18:5771-3 (2009) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50293171
Synonyms:
(1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydroxy-1',2,4,6,8,12,14,19-octamethyl-23,25,26,27-tetraoxaspiro[pentacyclo[18.5.1.1^{11,15}.0^{1,22}.0^{16,21}]heptacosane-24,4'-piperidine]-6,16(21),19-triene-17,18-dione | CHEMBL508232
Type:
Small organic molecule
Emp. Form.:
C35H51NO7
Mol. Mass.:
597.7819
SMILES:
C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]34OC5=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)=C5[C@H]3OC1(CCN(C)CC1)O4 |r,c:7,18,33|
Structure:
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