Reaction Details Report a problem with these data
Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM31892
Substrate
n/a
Meas. Tech.
ChEMBL_572202 (CHEMBL1029373)
EC50
200±n/a nM
Citation
 Pérez-Rodríguez, S; Ortiz, MA; Pereira, R; Rodríguez-Barrios, F; de Lera, AR; Piedrafita, FJ Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles. Eur J Med Chem 44:2434-46 (2009) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
Nr2b1 | RXRA_MOUSE | Retinoid X receptor alpha | Rxra
Type:
PROTEIN
Mol. Mass.:
51225.80
Organism:
Mus musculus
Description:
ChEMBL_196493
Residue:
467
Sequence:
MDTKHFLPLDFSTQVNSSSLNSPTGRGSMAVPSLHPSLGPGIGSPLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSTEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQAT
  
Inhibitor
Name:
BDBM31892
Synonyms:
9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin | alitretinoin
Type:
Small organic molecule
Emp. Form.:
C20H28O2
Mol. Mass.:
300.4351
SMILES:
C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4|
Structure:
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