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TargetPeroxisome proliferator-activated receptor alpha
LigandBDBM50293846
Substrate/Competitorn/a
Meas. Tech.ChEMBL_572395
EC50>1±n/a nM
Citation Liu, WLiu, KWood, HBMcCann, MEDoebber, TWChang, CHAkiyama, TEEinstein, MBerger, JPMeinke, PT Discovery of a peroxisome proliferator activated receptor gamma (PPARgamma) modulator with balanced PPARalpha activity for the treatment of type 2 diabetes and dyslipidemia. J Med Chem52:4443-53 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peroxisome proliferator-activated receptor alpha
Name:Peroxisome proliferator-activated receptor alpha
Synonyms:Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha
Type:PROTEIN
Mol. Mass.:52343.28
Organism:Mus musculus
Description:ChEMBL_572395
Residue:468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSC
PGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFV
IHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDT
FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
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  Blast E-value cutoff:
BDBM50293846
n/a
NameBDBM50293846
Synonyms:(+)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl]methyl]phenoxy}-2-methylbutanoic Acid | CHEMBL558083
TypeSmall organic molecule
Emp. Form.C29H25ClF3NO5
Mol. Mass.559.961
SMILESCC[C@@](C)(Oc1cccc(Cn2c(C)c(C(=O)c3ccc(Cl)cc3)c3ccc(OC(F)(F)F)cc23)c1)C(O)=O |r|
Structure
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