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Target
Prostaglandin E synthase
Ligand
BDBM50294195
Substrate
n/a
Meas. Tech.
ChEMBL_571973 (CHEMBL1036476)
IC50
3900±n/a nM
Citation
 Liedtke, AJ; Keck, PR; Lehmann, F; Koeberle, A; Werz, O; Laufer, SA Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). J Med Chem 52:4968-72 (2009) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50294195
Synonyms:
5-((1H-tetrazol-5-yl)methyl)-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine | CHEMBL564318
Type:
Small organic molecule
Emp. Form.:
C23H22ClN5
Mol. Mass.:
403.907
SMILES:
CC1(C)Cc2c(c(c(Cc3nnn[nH]3)n2C1)-c1ccc(Cl)cc1)-c1ccccc1
Structure:
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