Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 3
Ligand
BDBM50414490
Substrate
n/a
Meas. Tech.
ChEMBL_579670 (CHEMBL1064090)
EC50
<10000±n/a nM
Citation
 Skinner, PJ; Webb, PJ; Sage, CR; Dang, TH; Pride, CC; Chen, R; Tamura, SY; Richman, JG; Connolly, DT; Semple, G 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett 19:4207-9 (2009) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 3
Synonyms:
G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44498.06
Organism:
Homo sapiens (Human)
Description:
GPR109B 0 HUMAN::P49019
Residue:
387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
  
Inhibitor
Name:
BDBM50414490
Synonyms:
CHEMBL550153
Type:
Small organic molecule
Emp. Form.:
C14H13N3O3S
Mol. Mass.:
303.336
SMILES:
OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccco1
Structure:
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