Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50208138
Substrate
n/a
Meas. Tech.
ChEMBL_579669 (CHEMBL1064089)
EC50
1300±n/a nM
Citation
 Skinner, PJ; Webb, PJ; Sage, CR; Dang, TH; Pride, CC; Chen, R; Tamura, SY; Richman, JG; Connolly, DT; Semple, G 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett 19:4207-9 (2009) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50208138
Synonyms:
(+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid | 5-methyl-4-oxo-5-phenyl-4,5-dihydrofuran-2-carboxylic acid | CHEMBL278488 | acifran
Type:
Small organic molecule
Emp. Form.:
C12H10O4
Mol. Mass.:
218.2054
SMILES:
CC1(OC(=CC1=O)C(O)=O)c1ccccc1 |c:3|
Structure:
Search PDB for entries with ligand similarity: