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TargetAcyl-CoA desaturase 1
LigandBDBM50296530
Substrate/Competitorn/a
Meas. Tech.ChEMBL_582072
IC50 2±n/a nM
Citation Uto, YOgata, THarada, JKiyotsuka, YUeno, YMiyazawa, YKurata, HDeguchi, TWatanabe, NTakagi, TWakimoto, SOkuyama, RAbe, MKurikawa, NKawamura, SYamato, MOsumi, J Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide. Bioorg Med Chem Lett19:4151-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acyl-CoA desaturase 1
Name:Acyl-CoA desaturase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:41064.54
Organism:Mus musculus
Description:ChEMBL_1462109
Residue:355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEG
PPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWS
HRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGW
LLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVN
SLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTF
PFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
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  Blast E-value cutoff:
BDBM50296530
n/a
NameBDBM50296530
Synonyms:CHEMBL557652 | N-(5-(3,4-difluorobenzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamide
TypeSmall organic molecule
Emp. Form.C20H18F2N2O4S
Mol. Mass.420.43
SMILESCOc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2ccc(F)c(F)c2)s1
Structure
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