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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50297123
Substrate
n/a
Meas. Tech.
ChEMBL_581771 (CHEMBL1061558)
IC50
150±n/a nM
Citation
 Anderson, DR; Meyers, MJ; Kurumbail, RG; Caspers, N; Poda, GI; Long, SA; Pierce, BS; Mahoney, MW; Mourey, RJ; Parikh, MD Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency. Bioorg Med Chem Lett 19:4882-4 (2009) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM50297123
Synonyms:
(R)-9-Methyl-2-phenyl-8,9,10,11-tetrahydro-3-oxa-6-thia-8,11-diaza-cyclohepta[b]-as-indacen-7-one | CHEMBL562194
Type:
Small organic molecule
Emp. Form.:
C20H16N2O2S
Mol. Mass.:
348.418
SMILES:
C[C@@H]1CNc2c(sc3ccc4oc(cc4c23)-c2ccccc2)C(=O)N1 |r|
Structure:
Search PDB for entries with ligand similarity: