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TargetDelta-type opioid receptor
LigandBDBM50252876
Substrate/Competitorn/a
Meas. Tech.ChEMBL_583044
Ki 1.8±n/a nM
Citation Le Bourdonnec, BWindh, RTLeister, LKZhou, QJAjello, CWGu, MChu, GHTuthill, PABarker, WMKoblish, MWiant, DDGraczyk, TMBelanger, SCassel, JAFeschenko, MSBrogdon, BLSmith, SADerelanko, MJKutz, SLittle, PJDeHaven, RNDeHaven-Hudkins, DLDolle, RE Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). J Med Chem52:5685-702 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Delta-type opioid receptor
Name:Opioid receptors; mu/kappa/delta
Synonyms:D-OR-1 | DOR-1 | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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  Blast E-value cutoff:
BDBM50252876
NameBDBM50252876
Synonyms:CHEMBL494462 | N,N-Diethyl-4-(spiro[chromene-2,4'-piperidine]-4-yl)benzamide
TypeSmall organic molecule
Emp. Form.C24H28N2O2
Mol. Mass.376.4913
SMILESCCN(CC)C(=O)c1ccc(cc1)C1=CC2(CCNCC2)Oc2ccccc12 |t:14|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a