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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50298621
Substrate
n/a
Meas. Tech.
ChEMBL_587815 (CHEMBL1043093)
IC50
2.5±n/a nM
Citation
 Sakamoto, T; Moriya, M; Tsuge, H; Takahashi, T; Haga, Y; Nonoshita, K; Okamoto, O; Takahashi, H; Sakuraba, A; Hirohashi, T; Shibata, T; Kanno, T; Ito, J; Iwaasa, H; Gomori, A; Ishihara, A; Fukuroda, T; Kanatani, A; Fukami, T Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds. Bioorg Med Chem 17:5015-26 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50298621
Synonyms:
1-(Methylsulfonyl)-N-(quinolin-6-yl)-1,2-dihydro-1'H-spiro[indole-3,4'-piperidine]-1'-carboxamide | CHEMBL577794
Type:
Small organic molecule
Emp. Form.:
C23H24N4O3S
Mol. Mass.:
436.527
SMILES:
CS(=O)(=O)N1CC2(CCN(CC2)C(=O)Nc2ccc3ncccc3c2)c2ccccc12
Structure:
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