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TargetStearoyl-CoA desaturase 1 (SCD1)
LigandBDBM50298904
Substrate/Competitorn/a
Meas. Tech.ChEMBL_588105
IC50 1.9±n/a nM
Citation Koltun, DOZilbershtein, TMMigulin, VAVasilevich, NIParkhill, EQGlushkov, AIMcGregor, MJBrunn, SAChu, NHao, JMollova, NLeung, KChisholm, JWZablocki, J Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett19:4070-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Stearoyl-CoA desaturase 1 (SCD1)
Name:Stearoyl-CoA desaturase 1 (SCD1)
Synonyms:Acyl-CoA desaturase 1
Type:Enzyme
Mol. Mass.:41485.97
Organism:Rattus norvegicus (Rat)
Description:P07308
Residue:358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50298904
n/a
NameBDBM50298904
Synonyms:2-hydroxy-N-(2-(2-oxo-3-(trifluoromethyl)-7-(3-(trifluoromethyl)benzylamino)quinoxalin-1(2H)-yl)ethyl)acetamide | CHEMBL575817
TypeSmall organic molecule
Emp. Form.C21H18F6N4O3
Mol. Mass.488.383
SMILESOCC(=O)NCCn1c2cc(NCc3cccc(c3)C(F)(F)F)ccc2nc(c1=O)C(F)(F)F
Structure
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