Target
Neuromedin-K receptor
Ligand
BDBM50291261
Substrate
n/a
Meas. Tech.
ChEMBL_590803 (CHEMBL1037641)
Ki
0.8±n/a nM
Citation
 Malherbe, PKratzeisen, CMarcuz, AZenner, MTNettekoven, MHRatni, HWettstein, JGBissantz, C Identification of a critical residue in the transmembrane domain 2 of tachykinin neurokinin 3 receptor affecting the dissociation kinetics and antagonism mode of osanetant (SR 142801) and piperidine-based structures. J Med Chem 52:7103-12 (2009) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49456.44
Organism:
GUINEA PIG
Description:
Neurokinin NK3 TACR3 GUINEA PIG::P30098
Residue:
440
Sequence:
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
  
Inhibitor
Name:
BDBM50291261
Synonyms:
(S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl)-4-phenylpiperidin-4-yl)-N-methylacetamine | CHEMBL2311148 | CHEMBL346178 | N-(1-{3-[(R)-1-Benzoyl-3-(3,4-dichloro-phenyl)-piperidin-3-yl]-propyl}-4-phenyl-piperidin-4-yl)-N-methyl-acetamide | OSANETANT | SB-236984 | SR-14280 | SR-142801
Type:
Small organic molecule
Emp. Form.:
C35H41Cl2N3O2
Mol. Mass.:
606.625
SMILES:
CN(C(C)=O)C1(CCN(CCC[C@@]2(CCCN(C2)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: