Target
Cellular tumor antigen p53
Ligand
BDBM50299818
Substrate
n/a
Meas. Tech.
ChEMBL_589609 (CHEMBL1052162)
IC50
11400±n/a nM
Citation
 Allen, JGBourbeau, MPWohlhieter, GEBartberger, MDMichelsen, KHungate, RGadwood, RCGaston, RDEvans, BMann, LWMatison, MESchneider, SHuang, XYu, DAndrews, PSReichelt, ALong, AMYakowec, PYang, EYLee, TAOliner, JD Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem 52:7044-53 (2009) [PubMed]  Article 
Target
Name:
Cellular tumor antigen p53
Synonyms:
Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53
Type:
fusion protein
Mol. Mass.:
43654.73
Organism:
Homo sapiens (Human)
Description:
The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:
393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
  
Inhibitor
Name:
BDBM50299818
Synonyms:
(+/-)-syn-6,7-Bis(4-bromophenyl)-3-fluoro-2,12-dimethyl-7,12-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine | CHEMBL584512
Type:
Small organic molecule
Emp. Form.:
C26H19Br2FN4O
Mol. Mass.:
582.262
SMILES:
CN1c2ncnn2C(C2=C1c1cc(C)c(F)cc1OC2c1ccc(Br)cc1)c1ccc(Br)cc1 |c:9|
Structure:
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