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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM50300127
Substrate
n/a
Meas. Tech.
ChEMBL_593692 (CHEMBL1044145)
IC50
9.2E3±n/a nM
Citation
 Weber, JE; Oakley, AJ; Christ, AN; Clark, AG; Hayes, JD; Hall, R; Hume, DA; Board, PG; Smythe, ML; Flanagan, JU Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase. Eur J Med Chem 45:447-54 (2010) [PubMed]  Article 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM50300127
Synonyms:
CHEMBL567059 | NSC-4502 | phenyl(thiophen-2-yl)methanone
Type:
Small organic molecule
Emp. Form.:
C11H8OS
Mol. Mass.:
188.246
SMILES:
O=C(c1cccs1)c1ccccc1
Structure:
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