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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50300518
Substrate
n/a
Meas. Tech.
ChEMBL_592526 (CHEMBL1044082)
IC50
21±n/a nM
Citation
 Mahaney, PE; Kim, CY; Coghlan, RD; Cohn, ST; Heffernan, GD; Huselton, CA; Terefenko, EA; Vu, AT; Zhang, P; Burroughs, KD; Cosmi, SA; Bray, JA; Johnston, GH; Deecher, DC; Trybulski, EJ Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors. Bioorg Med Chem Lett 19:5807-10 (2009) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50300518
Synonyms:
(1S,2R)-1-(3-fluorophenyl)-1-(5-methyl-1H-indol-1-yl)-3-(methylamino)propan-2-ol | CHEMBL572927
Type:
Small organic molecule
Emp. Form.:
C19H21FN2O
Mol. Mass.:
312.3812
SMILES:
CNC[C@@H](O)[C@H](c1cccc(F)c1)n1ccc2cc(C)ccc12 |r|
Structure:
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