Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50300783
Substrate
n/a
Meas. Tech.
ChEMBL_591547 (CHEMBL1062953)
IC50
>50000±n/a nM
Citation
Mallari, JP; Shelat, AA; Kosinski, A; Caffrey, CR; Connelly, M; Zhu, F; McKerrow, JH; Guy, RK Structure-guided development of selective TbcatB inhibitors. J Med Chem 52:6489-93 (2009) [PubMed] Article
More Info.:
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Inhibitor
Name:
BDBM50300783
Synonyms:
9-(3-hydroxypropyl)-6-(3-(1-(phenylsulfonyl)-1H-indol-2-yl)benzylamino)-9H-purine-2-carbonitrile | CHEMBL574590
Type:
Small organic molecule
Emp. Form.:
C30H25N7O3S
Mol. Mass.:
563.63
SMILES:
OCCCn1cnc2c(NCc3cccc(c3)-c3cc4ccccc4n3S(=O)(=O)c3ccccc3)nc(nc12)C#N