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Target5-Hydroxytryptamine receptor 6 (5-HT6)
LigandBDBM50300825
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598759
EC50 15±n/a nM
Citation Bernotas, RCLenicek, SAntane, SCole, DCHarrison, BLRobichaud, AJZhang, GMSmith, DPlatt, BLin, QLi, PCoupet, JRosenzweig-Lipson, SBeyer, CESchechter, LE Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem17:5153-63 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-Hydroxytryptamine receptor 6 (5-HT6)
Name:5-Hydroxytryptamine receptor 6 (5-HT6)
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (human)
Description:Cultured Hela cells expressing h5-HT6 receptors.
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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  Blast E-value cutoff:
BDBM50300825
NameBDBM50300825
Synonyms:CHEMBL584046 | N,N-Dimethyl-N-(2-{3-[(3-chlorophenyl)sulfonyl]-1Hpyrrolo[2,3-b]pyridin-1-yl}ethyl)amine
TypeSmall organic molecule
Emp. Form.C17H18ClN3O2S
Mol. Mass.363.862
SMILESCN(C)CCn1cc(c2cccnc12)S(=O)(=O)c1cccc(Cl)c1
Structure
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