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Target
TGF-beta receptor type-1
Ligand
BDBM50148665
Substrate
n/a
Meas. Tech.
ChEMBL_598612 (CHEMBL1048115)
IC50
1300±n/a nM
Citation
 Ren, JX; Li, LL; Zou, J; Yang, L; Yang, JL; Yang, SY Pharmacophore modeling and virtual screening for the discovery of new transforming growth factor-beta type I receptor (ALK5) inhibitors. Eur J Med Chem 44:4259-65 (2009) [PubMed]  Article 
Target
Name:
TGF-beta receptor type-1
Synonyms:
ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I
Type:
enzyme
Mol. Mass.:
55968.24
Organism:
Homo sapiens (Human)
Description:
P36897
Residue:
503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM50148665
Synonyms:
4-(2-(6-isopropylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline | 4-[2-(6-Isopropyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline | CHEMBL120245
Type:
Small organic molecule
Emp. Form.:
C23H22N4
Mol. Mass.:
354.4476
SMILES:
CC(C)c1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccccc12 |(11.23,-4.96,;10.3,-3.73,;10.9,-2.31,;8.78,-3.92,;8.18,-5.36,;6.64,-5.57,;5.71,-4.32,;6.32,-2.91,;7.85,-2.71,;5.38,-1.68,;5.83,-.21,;4.55,.67,;4.06,2.11,;2.54,2.09,;2.08,.62,;3.34,-.26,;3.84,-1.71,;2.9,-2.93,;3.49,-4.36,;2.55,-5.57,;1.03,-5.38,;.44,-3.94,;-1.09,-3.76,;-1.68,-2.33,;-.74,-1.1,;.78,-1.3,;1.37,-2.73,)|
Structure:
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