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TargetPPYR1
LigandBDBM50301192
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598775
IC50>10000±n/a nM
Citation Kameda, MAndo, MNakama, CKobayashi, KKawamoto, HIto, SSuzuki, TTani, TOzaki, STokita, SSato, N Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors. Bioorg Med Chem Lett19:5124-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
PPYR1
Name:Neuropeptide Y receptor type 4
Synonyms:NPY-Y4 | NPY4-R | Neuropeptide Y receptor type 4 | PP1 | Pancreatic polypeptide receptor 1
Type:Enzyme Catalytic Domain
Mol. Mass.:42207.58
Organism:Homo sapiens (Human)
Description:NPY-Y4 PPYR1 HUMAN::P50391
Residue:375
Sequence:
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL
CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI
QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL
ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR
LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHG
NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE
VSKGSLRLSGRSNPI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50301192
NameBDBM50301192
Synonyms:6-((4-(fluoromethyl)-5-methylthiazol-2-ylthio)methyl)-N-((6-methylpyridin-2-yl)methyl)-4-morpholinopyridin-2-amine | CHEMBL585711
TypeSmall organic molecule
Emp. Form.C22H26FN5OS2
Mol. Mass.459.603
SMILESCc1sc(SCc2cc(cc(NCc3cccc(C)n3)n2)N2CCOCC2)nc1CF
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a