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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50301205
Substrate
n/a
Meas. Tech.
ChEMBL_598772 (CHEMBL1042012)
IC50
8±n/a nM
Citation
 Kameda, M; Ando, M; Nakama, C; Kobayashi, K; Kawamoto, H; Ito, S; Suzuki, T; Tani, T; Ozaki, S; Tokita, S; Sato, N Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors. Bioorg Med Chem Lett 19:5124-7 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50301205
Synonyms:
CHEMBL566441 | [6-(4,5-Dimethyl-oxazol-2-ylsulfanylmethyl)-4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-yl)-pyridin-2-yl]-(6-fluoro-pyridin-2-ylmethyl)-amine
Type:
Small organic molecule
Emp. Form.:
C21H24FN5O3S2
Mol. Mass.:
477.575
SMILES:
Cc1nc(SCc2cc(cc(NCc3cccc(F)n3)n2)N2CCS(=O)(=O)CC2)oc1C
Structure:
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