Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50303163
Substrate
n/a
Meas. Tech.
ChEMBL_594896 (CHEMBL1038947)
Ki
3.9±n/a nM
Citation
 Bernotas, RC; Antane, SA; Lenicek, SE; Haydar, SN; Robichaud, AJ; Harrison, BL; Zhang, GM; Smith, D; Coupet, J; Schechter, LE 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands. Bioorg Med Chem Lett 19:6935-8 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50303163
Synonyms:
1-(3-(4-bromophenylsulfonyl)-1-(2-(dimethylamino)ethyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)ethanone | CHEMBL572092
Type:
Small organic molecule
Emp. Form.:
C19H20BrN3O3S
Mol. Mass.:
450.349
SMILES:
CN(C)CCn1cc(c2nc(ccc12)C(C)=O)S(=O)(=O)c1ccc(Br)cc1
Structure:
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