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TargetEndothelin-converting enzyme 1 (ECE1)
LigandBDBM50303329
Substrate/Competitorn/a
Meas. Tech.ChEMBL_595726
Ki>10000±n/a nM
Citation Jullien, NMakritis, AGeorgiadis, DBeau, FYiotakis, ADive, V Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem53:208-20 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin-converting enzyme 1 (ECE1)
Name:Endothelin-converting enzyme 1
Synonyms:ECE-1 | Endothelin-Converting Enzyme 1
Type:Enzyme
Mol. Mass.:87155.11
Organism:Homo sapiens (Human)
Description:P42892
Residue:770
Sequence:
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50303329
NameBDBM50303329
Synonyms:(2S)-2-{[3-(3'-[1,1'-Biphenyl]-4''-yl-4',5'-dihydro-5'-isoxazolyl)-2-{[hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)-phosphinyl]methyl}-1-oxopropyl]amino}1H-Indole-3-propanoic Acid | CHEMBL570722
TypeSmall organic molecule
Emp. Form.C46H45N4O8P
Mol. Mass.812.8453
SMILESOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(CC1CC(=NO1)c1ccc(cc1)-c1ccccc1)CP(O)(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r,c:23|
Structure
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