Reaction Details Report a problem with these data
Target
Caspase-14
Ligand
BDBM50303410
Substrate
n/a
Meas. Tech.
ChEMBL_595880 (CHEMBL1040860)
IC50
14125.38±n/a nM
Citation
 Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem 53:52-60 (2010) [PubMed]  Article 
Target
Name:
Caspase-14
Synonyms:
CASP14 | CASPE_HUMAN
Type:
PROTEIN
Mol. Mass.:
27674.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_595880
Residue:
242
Sequence:
MSNPRSLEEEKYDMSGARLALILCVTKAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKRLYLQ
  
Inhibitor
Name:
BDBM50303410
Synonyms:
4-(3-chlorophenylamino)-6-(cyclopentylamino)-1,3,5-triazine-2-carbonitrile | CHEMBL567785
Type:
Small organic molecule
Emp. Form.:
C15H15ClN6
Mol. Mass.:
314.773
SMILES:
Clc1cccc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1
Structure:
Search PDB for entries with ligand similarity: