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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50304046
Substrate
n/a
Meas. Tech.
ChEMBL_601510 (CHEMBL1044205)
Ki
3.5±n/a nM
Citation
 Nielsen, S; Pedersen, CM; Hansen, SG; Petersen, MD; Sinning, S; Wiborg, O; Jensen, HH; Bols, M An extended study of dimeric phenyl tropanes. Bioorg Med Chem 17:4900-9 (2009) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50304046
Synonyms:
1-[3beta-(4-Chloro-phenyl)tropane-2beta-carbonyl-oxy]-7-[4-(3beta-{4-chloro-phenyl}tropane-2beta-carbonyl-oxy-methyl)-(1,2,3)triazol-1-yl]heptane | CHEMBL595190
Type:
Small organic molecule
Emp. Form.:
C40H51Cl2N5O4
Mol. Mass.:
736.77
SMILES:
CN1C2CCC1[C@@H]([C@H](C2)c1ccc(Cl)cc1)C(=O)OCCCCCCCn1cc(COC(=O)[C@@H]2C3CCC(C[C@@H]2c2ccc(Cl)cc2)N3C)nn1 |r,TLB:40:39:47:35.36,16:6:1:3.4,THB:9:7:1:3.4,31:33:47:35.36|
Structure:
Search PDB for entries with ligand similarity: