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Target
Endothelin-1 receptor
Ligand
BDBM50304497
Substrate
n/a
Meas. Tech.
ChEMBL_603857 (CHEMBL1046474)
Ki
1.26±n/a nM
Citation
 Höltke, C; Law, MP; Wagner, S; Kopka, K; Faust, A; Breyholz, HJ; Schober, O; Bremer, C; Riemann, B; Schäfers, M PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies. Bioorg Med Chem 17:7197-208 (2009) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_MOUSE | Ednra | Endothelin receptor ET-A | Gpcr10
Type:
PROTEIN
Mol. Mass.:
48591.87
Organism:
Mus musculus
Description:
ChEMBL_723169
Residue:
427
Sequence:
MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50304497
Synonyms:
2-(5-{[4-(Benzo[1,3]dioxol-5-yl)-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-yl]methyl}-2,3-dimethoxyphenoxy)ethyl 4-methylbenzenesulfonate | CHEMBL593928
Type:
Small organic molecule
Emp. Form.:
C36H34O12S
Mol. Mass.:
690.713
SMILES:
COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OCCOc2ccc(cc2)S(C)(=O)=O)c1)c1ccc2OCOc2c1 |c:14|
Structure:
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